Description

Chir-99021 is a potent and highly selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3), specifically targeting the GSK-3β isoform. This compound is a critical research tool for modulating the Wnt/β-catenin signaling pathway, which plays a fundamental role in cell proliferation, differentiation, and stem cell maintenance. It is essential for researchers and developers in the fields of stem cell biology, regenerative medicine, oncology research, and neurodegenerative disease studies.

Application

• Stem Cell Research & Maintenance: Used to maintain pluripotency and inhibit differentiation in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
• Regenerative Medicine: Investigated for its potential to enhance tissue repair and regeneration by promoting progenitor cell expansion.
• Oncology Research: Serves as a key pharmacological agent to study the role of Wnt/β-catenin signaling in cancer cell proliferation, survival, and drug resistance.
• Neurodegenerative Disease Models: Applied in research models for Alzheimer's disease, Parkinson's disease, and other conditions to explore neuroprotective effects.
• Biochemical & Cellular Pathway Analysis: A standard tool for dissecting the complex interactions within the GSK-3 and Wnt signaling networks.
• Drug Discovery & Development: Used as a reference compound and starting point for developing novel therapeutics targeting GSK-3.

Basic Information

Product Name	Chir-99021
CAS No.	252917-06-9
Molecular Formula	C₂₂H₁₈Cl₂N₈O
Molecular Weight	465.33 g/mol
Synonyms	CHIR-99021; CT99021; Laduviglusib; 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; GSK-3 Inhibitor XV; GSK-3β Inhibitor; CT 99021; CHIR99021
EINECS	Contact for details

Quality Control

Our Chir-99021 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and analytical methods are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.