Description

4-Trifluoromethyl-2-Hydroxy-Pyrimidine-5-Carboxylic Acid is a high-value fluorinated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethyl and carboxylic acid functionalities make it an essential intermediate for creating novel compounds with enhanced biological activity and physicochemical properties. This product is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science Research: Employed in the creation of novel fluorinated polymers, liquid crystals, and electronic materials.
• Chemical Biology Probes: Serves as a scaffold for designing enzyme inhibitors and molecular probes in biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in fluorochemistry.

Basic Information

Product Name	4-Trifluoromethyl-2-Hydroxy-Pyrimidine-5-Carboxylic Acid
CAS No.	251996-86-8
Molecular Formula	C6H3F3N2O3
Molecular Weight	208.10 g/mol
Synonyms	2-Hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylic acid; 5-Carboxy-4-(trifluoromethyl)-2-pyrimidinol; 4-(Trifluoromethyl)-2-pyrimidinol-5-carboxylic acid; 2-Pyrimidinol, 4-(trifluoromethyl)-5-carboxy-; 4-Trifluoromethyl-2-hydroxypyrimidine-5-carboxylic acid; 5-Pyrimidinecarboxylic acid, 4-(trifluoromethyl)-2-hydroxy-
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-2-Hydroxy-Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.