Description

Beloranib is a highly potent and selective methionine aminopeptidase 2 (MetAP2) inhibitor, representing a significant compound in pharmaceutical research and development. Its primary value lies in its targeted mechanism of action, which has been investigated for its potential therapeutic effects. This product is essential for research institutions, pharmaceutical companies, and biotechnology firms engaged in metabolic disorder research, oncology studies, and the development of novel anti-angiogenic therapies.

Application

• Pharmaceutical Research & Development: As a key investigational compound for studying metabolic pathways and angiogenesis.
• Preclinical Studies: Utilized in animal models to evaluate efficacy and pharmacokinetics for potential therapeutic applications.
• Biochemical Assay Development: Serves as a reference standard and active ingredient in developing high-throughput screening assays for MetAP2 inhibition.
• Mechanism of Action Studies: Critical for academic and industrial research focused on understanding the role of MetAP2 in cell proliferation and tumor growth.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Drug Discovery Programs: A vital building block in medicinal chemistry for synthesizing analogs and optimizing drug candidates.

Basic Information

Product Name	Beloranib
CAS No.	251111-30-5
Molecular Formula	C17H14F3N3O2S
Molecular Weight	381.37 g/mol
Synonyms	ZGN-433; (2S,3R)-3-Amino-2-hydroxy-4-[(4-methyl-1-piperazinyl)sulfonyl]-N-[(1R)-2,2,2-trifluoro-1-phenylethyl]butanamide; (αR)-α-[[(1S,2R)-3-Amino-1-hydroxy-2-[(4-methyl-1-piperazinyl)sulfonyl]propyl]thio]-2,2,2-trifluoro-N-(phenylmethyl)acetamide; Beloranibum; UNII-8JQ5607E5F
EINECS	Contact for details

Quality Control

Our Beloranib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We adhere to cGMP guidelines where applicable for the production of this pharmaceutical-grade intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.