Description

Z-Devd-Cmk is a specialized chemical intermediate, recognized for its role as a potent and selective inhibitor of cysteine proteases. This compound is critical for researchers and developers in the life sciences, providing a key tool for modulating enzymatic activity in biological systems. Its primary utility is found in advanced biochemical research, pharmaceutical development, and proteomics, where precise control over specific protease pathways is required.

Application

• Biochemical Research: Used as a selective, irreversible inhibitor for studying the function and mechanism of cysteine proteases like caspases and cathepsins.
• Pharmaceutical Development: Serves as a crucial pharmacophore or building block in the design and synthesis of novel therapeutic agents targeting protease-related diseases.
• Proteomics & Cell Biology: Employed in pathway analysis and apoptosis studies to selectively inhibit specific protease activity and elucidate cellular signaling mechanisms.
• Enzyme Characterization: Acts as an active site titrant and tool compound for determining the concentration and kinetic parameters of target enzymes.
• Diagnostic Reagent Development: Utilized in the formulation of assay kits and diagnostic tools for detecting and quantifying protease activity.

Basic Information

Product Name	Z-Devd-Cmk
CAS No.	250584-13-5
Molecular Formula	C24H34N4O7S
Molecular Weight	522.62 g/mol
Synonyms	Z-DEVD-CMK; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-CMK; Z-DEVD-Chloromethyl Ketone; Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-chloromethyl ketone; Caspase-3 Inhibitor II; Ac-DEVD-CMK (related analog); Caspase Inhibitor, Z-DEVD-; N-Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-chloromethyl ketone
EINECS	Contact for details

Quality Control

Our Z-Devd-Cmk is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and custom synthesis and purification to meet specific research-grade or GMP-grade requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.