Description

1-Bromo-4-(1,3-Dioxolan-2-Yl)-3-Fluorobenzene is a high-value, multi-functional aromatic building block designed for advanced organic synthesis. This compound matters for its unique molecular architecture, which combines halogen and protected aldehyde functionalities to enable precise and efficient construction of complex molecules. Pharmaceutical, agrochemical, and advanced material researchers need it as a critical intermediate for developing active ingredients and novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the fluorine and bromine substituents modulate biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic and display materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Functional Group Transformation: The 1,3-dioxolane group acts as a protected aldehyde, allowing for selective deprotection and further derivatization.
• Organic Synthesis Research: Employed in academic and industrial R&D for constructing complex, fluorinated biaryl and heterocyclic compounds.

Basic Information

Product Name	1-Bromo-4-(1,3-Dioxolan-2-Yl)-3-Fluorobenzene
CAS No.	248270-23-7
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	2-(4-Bromo-2-fluorophenyl)-1,3-dioxolane; 4-Bromo-2-fluorobenzaldehyde ethylene acetal; 1-Bromo-4-(1,3-dioxolan-2-yl)-3-fluorobenzene; 2-(4-Bromo-2-fluorophenyl)-[1,3]dioxolane; 4-Bromo-2-fluorophenyl-1,3-dioxolane; (4-Bromo-2-fluorophenyl)-1,3-dioxolane; Benzene, 1-bromo-4-(1,3-dioxolan-2-yl)-3-fluoro-
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(1,3-Dioxolan-2-Yl)-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.