Description

Desethylchloroquine Diphosphate Salt is a key pharmaceutical intermediate and metabolite of chloroquine. This compound is of significant importance for research and development in the fields of pharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in metabolic studies, bioanalytical method development, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of antimalarial and antiviral drug candidates.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies to quantify chloroquine and its metabolites in biological matrices.
• Pharmacokinetic Research: Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of chloroquine-based therapies.
• Analytical Chemistry: Serves as a high-purity standard for HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate mechanisms of action and potential off-target effects.
• Impurity Profiling: Used to identify and quantify related substances in active pharmaceutical ingredient (API) batches for regulatory compliance.

Basic Information

Product Name	Desethylchloroquine Diphosphate Salt
CAS No.	247912-76-1
Molecular Formula	C16H28ClN3O8P2
Molecular Weight	511.81 g/mol
Synonyms	N-Desethylchloroquine Diphosphate; N-Desethylchloroquine Bis(phosphate); 4-N-Desethyl-7-chloroquinoline Diphosphate; 1-{4-[(7-Chloroquinolin-4-yl)amino]pentyl}-4-(diethylamino)butylamine Diphosphate; Desethyl Chloroquine Diphosphate; Chloroquine Desethyl Metabolite Diphosphate Salt; WR 30090 Diphosphate (obsolete code).
EINECS	Contact for details

Quality Control

Our Desethylchloroquine Diphosphate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.