Description

2,4-Difluoro-5-(Trifluoromethyl)Bromobenzene is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as cross-coupling reactions and the development of active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the difluoro and trifluoromethyl groups enhance biological activity and environmental persistence.
• Cross-Coupling Reactions: Serves as an excellent electrophile in Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromine atom, enabling efficient carbon-carbon and carbon-heteroatom bond formation.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated components in electronic materials, where fluorine atoms improve thermal stability, charge transport, and optical properties.
• Polymer Modification: Incorporated as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, lowering surface energy, and improving durability.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2,4-Difluoro-5-(Trifluoromethyl)Bromobenzene
CAS No.	247220-84-4
Molecular Formula	C7H2BrF5
Molecular Weight	260.99 g/mol
Synonyms	1-Bromo-2,4-difluoro-5-(trifluoromethyl)benzene; 5-Bromo-2,4-difluorobenzotrifluoride; 2,4-Difluoro-5-(trifluoromethyl)phenyl bromide; 2,4-Difluoro-alpha,alpha,alpha,5-tetrabromotoluene; Benzene, 1-bromo-2,4-difluoro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2,4-difluorobromobenzene
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-(Trifluoromethyl)Bromobenzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency to meet the rigorous demands of process chemistry and scale-up. Comprehensive analytical testing, including GC, HPLC, and NMR, is performed to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its sensitivity to light, the container should be opaque or stored in dark conditions. For long-term storage, consider using an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.