Description

Indirubin-5-Sulfonate is a sulfonated derivative of the natural bisindole alkaloid indirubin, known for its enhanced solubility and bioactivity profile. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a kinase inhibitor with applications in oncology and inflammatory disease pathways. It serves as a critical high-purity reference standard and active pharmaceutical ingredient (API) intermediate for researchers and manufacturers in the life sciences sector.

Application

• Pharmaceutical Research: As a key intermediate or reference standard in the development of kinase-targeted therapies for cancer and chronic inflammatory conditions.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro studies to investigate cell signaling pathways and mechanism of action.
• Academic Research: Serves as a tool compound in universities and research institutes for studying cell cycle regulation, apoptosis, and differentiation.
• Preclinical Development: Used in formulation studies and pharmacokinetic/pharmacodynamic (PK/PD) modeling for potential drug candidates.
• Analytical Standard: Acts as a certified reference material (CRM) for quality control and method validation in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	Indirubin-5-Sulfonate
CAS No.	244021-67-8
Molecular Formula	C16H10N2O4S
Molecular Weight	326.33 g/mol
Synonyms	Indirubin 5-Sulfonic Acid; 5-Sulfoindirubin; 2,3-Bis(3-hydroxy-1H-indol-2-yl)-2,4-cyclopentadien-1-one 5-sulfonate; Indirubin-5-SO3H; 1H-Indole-5-sulfonic acid, 2,3-dihydro-2,3-bis(3-hydroxy-1H-indol-2-yl)-, (2Z,3Z)-; EINECS Contact for details

Quality Control

Our Indirubin-5-Sulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and analytical method validation to support its use in regulated research environments. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Reddish-brown to dark brown powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.