Description

Resatorvid is a potent and selective small-molecule inhibitor of Toll-like receptor 4 (TLR4), a key mediator of innate immune responses. This compound is a critical research tool for investigating inflammatory pathways and has significant potential in preclinical studies for conditions involving dysregulated inflammation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology, sepsis, and autoimmune disease research.

Application

• Biomedical Research: A fundamental tool for studying TLR4 signaling pathways, NF-κB activation, and cytokine production in in vitro and in vivo models.
• Preclinical Drug Development: Used to validate TLR4 as a therapeutic target in candidate screening and efficacy studies for inflammatory and autoimmune disorders.
• Sepsis and Endotoxemia Studies: Investigated for its potential to attenuate the systemic inflammatory response in experimental models of sepsis.
• Neuroinflammation Research: Applied in studies exploring the role of TLR4 in neurodegenerative diseases, neuropathic pain, and central nervous system injuries.
• Metabolic Disease Research: Utilized in models of insulin resistance and non-alcoholic fatty liver disease to understand the link between inflammation and metabolism.
• Cell Culture & Assay Development: Serves as a critical control and experimental compound in high-throughput screening and mechanistic assay development.

Basic Information

Product Name	Resatorvid
CAS No.	243984-11-4
Molecular Formula	C₁₉H₁₇FN₂O₄
Molecular Weight	356.35 g/mol
Synonyms	TAK-242; CLI-095; Resatorvid; Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate; TLR4 Inhibitor TAK-242; Cyclohexene TLR4 Inhibitor
EINECS	Contact for details

Quality Control

Our Resatorvid is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high-purity standards typical for advanced pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.