Description

Pdhk Inhibitor CAS NO 243982-58-3 is a potent and selective small molecule inhibitor of pyruvate dehydrogenase kinase (PDHK), a key regulatory enzyme in cellular energy metabolism. This compound is a critical research tool for modulating the pyruvate dehydrogenase complex (PDC) activity, which governs the crucial link between glycolysis and the tricarboxylic acid (TCA) cycle. It is primarily utilized by researchers and developers in the fields of metabolic disease research, oncology, and pharmaceutical development to investigate metabolic reprogramming, cancer cell survival, and potential therapeutic interventions.

Application

• Biochemical Research: Used as a selective tool compound to study the role of PDHK in cellular metabolism, glucose oxidation, and the Warburg effect in cancer cells.
• Oncology Research: Investigated for its potential to inhibit cancer cell proliferation by forcing oxidative metabolism and reducing the glycolytic flux essential for many tumors.
• Metabolic Disorder Studies: Applied in research models of diabetes and insulin resistance to understand and modulate mitochondrial function and glucose homeostasis.
• Pharmaceutical Screening: Serves as a reference standard or lead compound in high-throughput screening campaigns for novel PDHK-targeting therapeutics.
• Cell Culture & In Vitro Assays: Employed to manipulate metabolic pathways in various cell lines to observe downstream effects on signaling, growth, and apoptosis.
• Preclinical Development: Supports proof-of-concept studies for new drug candidates aimed at metabolic modulation in disease states.

Basic Information

Item	Detail
Product Name	Pdhk Inhibitor
CAS No.	243982-58-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PDHK Inhibitor; PDK Inhibitor; Pyruvate Dehydrogenase Kinase Inhibitor; Dichloroacetate (DCA) analogue; 2,2-Dichloroacetamide derivative; Metabolic Modulator; CAS 243982-58-3
EINECS	Contact for details

Quality Control

Our Pdhk Inhibitor is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC and structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and analytical data is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.