Description

2,4,5-Trifluorobenzyl Chloride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the reactivity of the benzyl chloride group combined with the unique electronic properties imparted by the trifluoro substitution pattern, enabling precise molecular construction. This compound is essential for research and production chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystals used in high-performance displays (LCDs).
• Organic Electronics: Employed in the development of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl structures.
• Derivatization Agent: Used to introduce the 2,4,5-trifluorobenzyl moiety onto other molecules, modifying their physical and chemical properties.

Basic Information

Product Name	2,4,5-Trifluorobenzyl Chloride
CAS No.	243139-71-1
Molecular Formula	C7H4ClF3
Molecular Weight	192.55 g/mol
Synonyms	1-(Chloromethyl)-2,4,5-trifluorobenzene; (2,4,5-Trifluorophenyl)methyl chloride; α-Chloro-2,4,5-trifluorotoluene; 2,4,5-Trifluorobenzylchloride; 2,4,5-Trifluoro-α-chlorotoluene; Benzene, 1-(chloromethyl)-2,4,5-trifluoro-; 2,4,5-Trifluoro-1-(chloromethyl)benzene
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and GC-MS, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.