Description

Zoniporide CAS NO 241800-98-6 is a potent and selective inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1), a key target in cardiovascular research. This compound is critical for investigating cellular mechanisms related to ischemia-reperfusion injury and myocardial protection. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on developing novel cardioprotective therapeutics.

Application

• Cardiovascular Research: A key pharmacological tool for studying the role of NHE-1 in cardiac ischemia, reperfusion injury, and myocardial infarction models.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of new NHE-1 inhibitor candidates for cardioprotection.
• Biochemical Assays: Used in in vitro enzymatic and cellular assays to characterize NHE-1 activity and inhibitor potency.
• Preclinical Studies: Employed in animal models to evaluate the efficacy of NHE-1 inhibition in reducing infarct size and improving cardiac function post-ischemia.
• Mechanistic Pharmacology: Essential for elucidating intracellular pH regulation and sodium-calcium exchanger interactions in cardiac myocytes.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	Zoniporide
CAS No.	241800-98-6
Molecular Formula	C15H17FN4O2
Molecular Weight	304.32 g/mol
Synonyms	Zoniporide; 1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid (2-fluorophenyl)amide; 5-Cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxylic acid 2-fluorophenylamide; CP-597,396; NHE-1 Inhibitor
EINECS	Contact for details

Quality Control

Our Zoniporide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical development and preclinical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.