Description

5-Bromo-1,2-Difluoro-3-Trifluoromethyl-Benzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs where it can modulate bioavailability, metabolic stability, and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the halogenated benzene core contributes to biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Fluorine Chemistry Research: An essential reagent for studying the effects of multiple fluorine atoms and the CF3 group on aromatic systems, relevant for drug discovery and catalyst design.
• Ligand and Catalyst Development: Used to synthesize novel, electron-deficient ligands for metal complexes used in catalysis and organic transformations.

Basic Information

Product Name	5-Bromo-1,2-Difluoro-3-Trifluoromethyl-Benzene
CAS No.	240122-25-2
Molecular Formula	C7H2BrF5
Molecular Weight	260.99 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-(trifluoromethyl)benzene; 2,3-Difluoro-5-bromobenzotrifluoride; 5-Bromo-1,2-difluoro-3-(trifluoromethyl)benzene; 5-Bromo-α,α,α,2,3-pentafluorotoluene; Benzene, 5-bromo-1,2-difluoro-3-(trifluoromethyl)-; 240122-25-2; 5-Bromo-2,3-difluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-1,2-Difluoro-3-Trifluoromethyl-Benzene adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.