Description

2-Fluoro-4-Iodo-1-(Trifluoromethyl)Benzene is a high-value, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring fluorine, iodine, and a trifluoromethyl group, makes it a versatile precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine and iodine atoms to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the halogenated benzene core contributes to biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck), enabling rapid diversification of the benzene core.
• Fluorine Chemistry Research: An important substrate for studying nucleophilic aromatic substitution and other reactions involving activated fluoroarenes.
• Ligand and Catalyst Development: Employed to synthesize sophisticated ligands for catalysis or as a scaffold for creating novel organocatalysts.

Basic Information

Product Name	2-Fluoro-4-Iodo-1-(Trifluoromethyl)Benzene
CAS No.	239135-53-6
Molecular Formula	C7H3F4I
Molecular Weight	305.99 g/mol
Synonyms	1-Fluoro-2-Iodo-5-(Trifluoromethyl)Benzene; 2-Fluoro-α,α,α,4-Tetraiodotoluene; 4-Iodo-2-Fluorobenzotrifluoride; 2-Fluoro-4-Iodobenzotrifluoride; 4-Iodo-2-Fluoro(trifluoromethyl)benzene; 1-(Trifluoromethyl)-2-fluoro-4-iodobenzene; 2-Fluoro-4-iodo-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Iodo-1-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.