Description

3-Fluoro-5-(Trifluoromethyl)Benzyl Bromide is a versatile and highly reactive benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of fluorine and bromine substituents, enabling precise molecular modifications to enhance the properties of target compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with improved efficacy and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drug candidates for CNS disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl and fluorine groups contribute to enhanced biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs), contributing to improved charge transport and stability.
• Functional Material Research: Employed in academic and industrial R&D to create novel polymers, ligands for catalysis, and advanced materials with tailored surface properties.
• Cross-Coupling Reactions: Acts as an efficient electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl and conjugated systems.
• Derivatization Agent: Utilized to introduce the 3-fluoro-5-(trifluoromethyl)benzyl moiety into larger molecular scaffolds, modifying solubility, lipophilicity, and metabolic stability.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethyl)Benzyl Bromide
CAS No.	239087-09-3
Molecular Formula	C8H5BrF4
Molecular Weight	257.03 g/mol
Synonyms	α-Bromo-3-fluoro-5-(trifluoromethyl)toluene; (3-Fluoro-5-(trifluoromethyl)phenyl)methyl bromide; 1-(Bromomethyl)-3-fluoro-5-(trifluoromethyl)benzene; 3-Fluoro-5-trifluoromethylbenzyl Bromide; 3-Fluoro-α-bromo-α,α,α-trifluoro-p-xylene; 239087-09-3; 3-Fluoro-5-(trifluoromethyl)benzylbromide
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality ensures reliable performance in your most sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.