Description

Alsterpaullone is a potent and selective small-molecule inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3). This compound is a critical research tool for studying cell cycle regulation, signal transduction pathways, and neurodegenerative disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and metabolic disorders. Alsterpaullone CAS NO 237430-03-4 offers high biological activity and specificity, making it an essential reagent for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the roles of CDK1, CDK2, CDK5, and GSK-3β in cellular processes.
• Oncology Research: Investigated for its potential to induce cell cycle arrest and apoptosis in various cancer cell lines.
• Neurodegenerative Disease Studies: Applied in models of Alzheimer's disease and tauopathies due to its GSK-3 inhibition, which affects tau protein phosphorylation.
• Stem Cell Research: Utilized to modulate signaling pathways involved in stem cell maintenance and differentiation.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool for validating new therapeutic targets in preclinical stages.
• Signal Transduction Analysis: Helps elucidate the Wnt/β-catenin and other kinase-dependent signaling cascades.

Basic Information

Product Name	Alsterpaullone
CAS No.	237430-03-4
Molecular Formula	C₁₆H₁₀BrN₃O₂
Molecular Weight	356.17 g/mol
Synonyms	9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; NSC 705701; ALP; 9-Bromo-paullone
EINECS	Contact for details

Quality Control

Our Alsterpaullone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.