Description

Mmp-8 Inhibitor I CAS NO 236403-25-1 is a potent and selective small molecule inhibitor of Matrix Metalloproteinase-8 (MMP-8, also known as Collagenase-2). This compound is a critical research tool for investigating the role of MMP-8 in inflammatory processes, tissue remodeling, and various disease pathologies. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Biochemical Research: Used as a selective inhibitor to study the enzymatic activity and substrate specificity of MMP-8 in in vitro assays.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the development of novel therapeutics targeting MMP-8 for conditions like rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and cancer metastasis.
• Cell Biology Studies: Applied in cell culture models to elucidate the functional role of MMP-8 in cellular signaling, extracellular matrix degradation, and inflammatory responses.
• Target Validation: Employed to validate MMP-8 as a therapeutic target in preclinical models of inflammation and tissue injury.
• Enzyme Kinetics: Utilized to determine inhibition constants (Ki, IC50) and study the mechanism of action against MMP-8.

Basic Information

Product Name	Mmp-8 Inhibitor I
CAS No.	236403-25-1
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	MMP-8 Inhibitor I; NSC 405020; (2R)-N-Hydroxy-1-[(2-methyl-4-quinolinyl)methyl]-4-(phenylsulfonyl)-2-piperidinecarboxamide; SB-3CT analog; MMP8 Inhibitor; Collagenase-2 Inhibitor I
EINECS	Contact for details

Quality Control

Our Mmp-8 Inhibitor I is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.