Description

Tobramycin A is a potent aminoglycoside antibiotic compound, specifically a key intermediate in the synthesis of the clinically important antibiotic Tobramycin. This high-purity chemical building block is critical for ensuring the efficacy and safety of the final pharmaceutical product. It is primarily required by manufacturers in the pharmaceutical and biotechnology sectors for the research, development, and production of advanced antibiotic formulations.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of the antibiotic Tobramycin (Nebcin®).
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of Tobramycin API under current Good Manufacturing Practice (cGMP) standards.
• Research & Development: Employed in medicinal chemistry research for developing novel aminoglycoside derivatives with improved properties.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Biochemical Research: Applied in studies investigating the mechanism of action of aminoglycoside antibiotics against bacterial ribosomes.

Basic Information

Product Name	Tobramycin A
CAS No.	236401-43-7
Molecular Formula	C18H37N5O9
Molecular Weight	467.51 g/mol
Synonyms	5-Deoxy-3'-deoxy-3'-fluorokanamycin B; 3'-Deoxy-3'-fluorokanamycin B; 3'-Deoxy-3'-fluoro-kanamycin B; Nebramycin Factor 5'; 3'-Fluoro-3'-deoxykanamycin B; TOB A; Tobramycin Impurity A (EP); Tobramycin Related Compound A (USP)
EINECS	Contact for details

Quality Control

Our Tobramycin A is manufactured and tested to meet exacting standards for pharmaceutical intermediates. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR). We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory filings and ensure supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.