Description

Seco-Duocarmycin Tm is a synthetic derivative of the potent antitumor antibiotic duocarmycin, representing a key intermediate in the development of novel cytotoxic agents. Its significance lies in its role as a precursor for antibody-drug conjugates (ADCs) and other targeted cancer therapeutics, enabling the creation of highly potent payloads. This compound is essential for pharmaceutical R&D teams, medicinal chemists, and manufacturers focused on advancing next-generation oncology treatments and precision medicine.

Application

• Antibody-Drug Conjugate (ADC) Payload Synthesis: Serves as a critical building block for constructing the potent warhead component of targeted cancer therapies.
• Medicinal Chemistry Research: Used in the design and synthesis of novel analogs for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Oncology Drug Development: Acts as a key intermediate in the production pathway for experimental small-molecule chemotherapeutic agents.
• Bioconjugation Studies: Employed in developing linker technologies to attach cytotoxic agents to targeting molecules like antibodies or peptides.
• Pharmacological Probe Development: Utilized to create tools for studying DNA alkylation mechanisms and cellular apoptosis pathways.
• Pre-clinical Candidate Optimization: Integral to scaling up and refining the synthesis of promising drug candidates for IND-enabling studies.

Basic Information

Product Name	Seco-Duocarmycin Tm
CAS No.	236102-87-7
Molecular Formula	C31H38N4O7
Molecular Weight	578.66 g/mol
Synonyms	Seco-Duocarmycin TM; (1S,8S,20S)-20-[(Cyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-yl)carbonyl]-1,8-dimethyl-4,10,21-trioxo-2,7,19-trioxa-5,11,20-triazatricyclo[14.3.1.13,8]henicosa-3,5,11,13,15-pentaene-9-carboxylic Acid; Duocarmycin SA Intermediate; CC-1065 Analog; ADC Payload Intermediate; DNA Alkylating Agent Intermediate
EINECS	Contact for details

Quality Control

Every batch of Seco-Duocarmycin Tm is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support pharmaceutical development, including identity confirmation, purity assessment, and impurity profiling. A Certificate of Analysis (COA) detailing specifications such as HPLC purity, related substances, and residual solvents is available for each lot to ensure compliance with your research and cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.