Description

(R)-Ketorolac Glucuronide is a key metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketorolac, specifically the glucuronide conjugate of its (R)-enantiomer. This compound is of significant importance in pharmaceutical research and development, particularly for metabolic profiling, pharmacokinetic studies, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism and safety evaluation.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of ketorolac metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance mechanisms, and bioavailability of ketorolac.
• Analytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or GC-MS methods for bioanalysis.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential toxicity of ketorolac metabolites.
• Impurity Profiling: Acts as a known impurity or degradation product standard for ketorolac drug substance and product quality control.
• Clinical Research: Supports studies monitoring patient metabolite levels for efficacy and safety correlations.

Basic Information

Product Name	(R)-Ketorolac Glucuronide
CAS No.	233666-91-6
Molecular Formula	C25H24N2O10
Molecular Weight	512.47 g/mol
Synonyms	(R)-Ketorolac Glucuronide; (R)-Ketorolac β-D-Glucuronide; (2R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid β-D-glucopyranosiduronic acid; Ketorolac (R)-Glucuronide; Ketorolac Tromethamine Metabolite; Toradol Metabolite; (R)-Ketorolac O-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our (R)-Ketorolac Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications can be aligned with pharmacopeial guidelines for reference standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.