Description

Bay 36-7620 is a high-purity, non-competitive antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5). This compound is a critical research tool for investigating glutamatergic signaling pathways in the central nervous system. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and contract research organizations (CROs) for preclinical studies in neurology and psychiatry.

Application

• Neuroscience Research: Fundamental studies on the role of mGluR5 in synaptic plasticity, learning, and memory.
• Drug Discovery & Development: A key reference standard and pharmacological tool for screening and validating novel mGluR5-targeting therapeutics.
• Preclinical Disease Modeling: Used in animal models to explore therapeutic potential for conditions like Fragile X syndrome, anxiety, depression, and Parkinson's disease.
• Biochemical Assay Development: Serves as a control compound in high-throughput screening (HTS) and receptor binding assays.
• Academic & Institutional Research: Supports grant-funded projects investigating glutamate receptor function and neurological disorders.

Basic Information

Product Name	Bay 36-7620
CAS No.	232605-26-4
Molecular Formula	C16H12F4N4O2
Molecular Weight	368.29 g/mol
Synonyms	2-Methyl-6-(phenylethynyl)pyridine; MPEP; Fenobam; CFMTI; (2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine derivative; mGluR5 antagonist; GRN-529; AFQ-056 (related analog)
EINECS	Contact for details

Quality Control

Every batch of Bay 36-7620 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) with detailed HPLC chromatograms and spectroscopic data are supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.