Description

n-Fluoro-6-(Trifluoromethyl)Pyridinium-2-Sulfonate is a high-value, specialty fluorinated pyridinium salt used as a key reagent in advanced organic synthesis. Its primary value lies in its ability to act as a versatile electrophilic fluorinating agent, introducing fluorine atoms into complex molecular frameworks under controlled conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise fluorination to modulate the biological activity, metabolic stability, and physical properties of target molecules.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for the late-stage fluorination of drug candidates, enhancing their potency and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiles.
• Agrochemical Development: Used in the synthesis of novel herbicides, pesticides, and fungicides where fluorination improves efficacy and environmental persistence.
• Positron Emission Tomography (PET) Tracer Production: Serves as a precursor or fluorination agent in the synthesis of fluorine-18 (18F) labeled radiopharmaceuticals for medical imaging.
• Advanced Material Research: Employed to create fluorinated polymers, liquid crystals, and electronic materials with unique thermal, chemical, and surface properties.
• Organic Methodology Development: A valuable tool for academic and industrial R&D focused on discovering new C-F bond-forming reactions and catalytic cycles.
• Fine Chemical Manufacturing: Enables the production of custom fluorinated building blocks and scaffolds for contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	n-Fluoro-6-(Trifluoromethyl)Pyridinium-2-Sulfonate
CAS No.	231285-89-5
Molecular Formula	C7H4F4NO3S
Molecular Weight	258.17 g/mol
Synonyms	1-Fluoro-6-(trifluoromethyl)pyridin-1-ium-2-sulfonate; 2-Pyridinesulfonic acid, 1-fluoro-6-(trifluoromethyl)-, inner salt; N-Fluoro-6-(trifluoromethyl)pyridinium-2-sulfonate; 6-(Trifluoromethyl)-N-fluoropyridinium-2-sulfonate; N-Fluoropyridinium-2-sulfonate derivative; Electrophilic fluorinating agent 231285-89-5; NFP-TFMS
EINECS	Contact for details

Quality Control

Our n-Fluoro-6-(Trifluoromethyl)Pyridinium-2-Sulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive fluorination reactions. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable, and our quality system is designed to meet the rigorous demands of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.