Description

4-Bromobenzyl-D6 Bromide is a deuterated isotopologue of 4-bromobenzyl bromide, where six hydrogen atoms are replaced by deuterium, making it a valuable stable isotope-labeled compound. This deuteration provides a critical internal standard for precise quantitative analysis in mass spectrometry, eliminating interference from endogenous compounds. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for drug metabolism studies, pharmacokinetic research, and the development of high-precision analytical methods.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of benzyl bromide derivatives and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmaceutical Research & Development: Used in drug discovery and development for tracing metabolic pathways, conducting absorption, distribution, metabolism, and excretion (ADME) studies, and ensuring regulatory compliance in bioanalytical method validation.
• Metabolomics and Proteomics: Enables precise relative and absolute quantification in high-throughput '-omics' studies, facilitating the discovery of biomarkers and understanding of disease mechanisms.
• Synthetic Intermediate: Acts as a deuterium-labeled building block for the synthesis of more complex labeled target molecules, preserving the isotopic label for downstream analytical tracking.
• Environmental and Food Safety Testing: Applied in residue analysis for pesticides, contaminants, and toxins, where high specificity and accuracy are required to meet stringent safety standards.

Basic Information

Product Name	4-Bromobenzyl-D6 Bromide
CAS No.	229948-68-9
Molecular Formula	C7D6Br2
Molecular Weight	265.94 g/mol
Synonyms	(4-Bromophenyl)-D5-d6-methylene Bromide; alpha,alpha,alpha,2,3,5,6-Heptadeutero-4-Bromobenzyl Bromide; 4-Bromobenzyl-d6 Bromide; 1-(Bromomethyl)-4-bromobenzene-D6; Benzene-D5, 1-(bromomethyl)-4-bromo-; p-Bromobenzyl-d6 Bromide; Deutero-p-Bromobenzyl Bromide
EINECS	Contact for details

Quality Control

Every batch of 4-Bromobenzyl-D6 Bromide is manufactured and tested under strict quality management protocols to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including NMR, HPLC, and mass spectrometry, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic purity (D-enrichment), chemical purity, and analytical methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.