Description

trans-3,4-Bis(Hydroxymethyl)-2,2,5,5-Tetramethylpyrrolidin-1-Yloxyl CAS NO 229621-07-2 is a stable nitroxide radical derivative, widely recognized as a versatile spin label and probe in advanced research. This compound is critical for studying molecular dynamics, protein structure, and polymer behavior through techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. It is an essential tool for researchers and developers in the fields of biophysics, structural biology, and materials science.

Application

• Spin Labeling in Biophysics: Site-directed spin labeling (SDSL) of proteins and nucleic acids to investigate structure, folding, and conformational changes.
• EPR Spectroscopy Studies: Serving as a stable paramagnetic probe for measuring distances, dynamics, and local environment in complex biological and chemical systems.
• Polymer & Materials Science: Use as a radical trap or probe to study polymerization kinetics, polymer chain mobility, and degradation mechanisms.
• Oxidation & Antioxidant Research: Acting as a model compound or radical scavenger in studies of oxidative stress and redox processes.
• MRI Contrast Agent Development: Potential use as a building block for developing novel redox-sensitive or targeted contrast agents.
• Catalysis & Mechanistic Studies: Employed as a radical initiator or mechanistic probe in organic synthesis and catalytic cycles.

Basic Information

Product Name	trans-3,4-Bis(Hydroxymethyl)-2,2,5,5-Tetramethylpyrrolidin-1-Yloxyl
CAS No.	229621-07-2
Molecular Formula	C11H22NO3
Molecular Weight	216.30 g/mol
Synonyms	3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-oxyl; trans-3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-1-oxyl; trans-3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-1-oxyl free radical; 3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-1-oxyl; 3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-1-oxyl radical; 3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-N-oxyl; trans-3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-N-oxyl; 3,4-Bis(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-N-oxyl radical
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Quality Control

Our trans-3,4-Bis(Hydroxymethyl)-2,2,5,5-Tetramethylpyrrolidin-1-Yloxyl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and EPR spectroscopy to confirm identity, purity, and radical content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability of the nitroxide radical. Keep the container sealed in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (EPR)	Characteristic triplet signal
Purity (HPLC)	≥ 98.0%
Assay (Radical Content)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.