Description

2-Hydroxymelatonin is a primary metabolite of melatonin, the key hormone regulating circadian rhythms. This compound is of significant interest in biochemical research for studying melatonin's metabolic pathways and its physiological effects. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and life science sectors, particularly for developing analytical methods and investigating neuroendocrine functions.

Application

• Biochemical Research Standard: Used as a high-purity reference material in analytical laboratories for method development and validation in melatonin metabolism studies.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor or metabolite standard in the development and quality control of melatonin-based therapeutics and supplements.
• Metabolite Analysis: Essential for quantitative analysis in pharmacokinetic and pharmacodynamic studies to understand melatonin absorption, distribution, metabolism, and excretion.
• Neuroendocrine Research: Employed in in-vitro and in-vivo studies to investigate the role of melatonin and its metabolites in sleep regulation, antioxidant activity, and immune modulation.
• Diagnostic Development: Used in the development of immunoassays (ELISA, RIA) and chromatographic assays (HPLC, LC-MS/MS) for clinical and research diagnostics.

Basic Information

Product Name	2-Hydroxymelatonin
CAS No.	229018-17-1
Molecular Formula	C13H16N2O3
Molecular Weight	248.28 g/mol
Synonyms	2-Hydroxymelatonin; 2-OH-Melatonin; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide; 5-Hydroxy-N-acetyltryptamine; Melatonin 2-hydroxylate; 6-Hydroxymelatonin isomer; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Hydroxymelatonin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.