Description

Ki8751 is a potent and selective small-molecule inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key target in angiogenesis research. This compound is crucial for studying intracellular signaling pathways and the role of VEGFR2 in tumor growth, metastasis, and other pathological conditions involving blood vessel formation. It is an essential research tool for scientists and pharmaceutical developers in the fields of oncology, cardiovascular disease, and anti-angiogenic drug discovery.

Application

• Biochemical Research: Used as a selective VEGFR2/KDR inhibitor to study tyrosine kinase signaling cascades and angiogenesis mechanisms in vitro.
• Pharmaceutical R&D: Serves as a reference compound and a lead structure in the development of novel anti-angiogenic and anti-cancer therapeutics.
• Cell Biology Studies: Employed to investigate the role of VEGFR2 in endothelial cell proliferation, migration, and survival under various experimental conditions.
• Preclinical Research: Utilized in animal models to validate the therapeutic potential of VEGFR2 inhibition for treating cancers and other angiogenesis-dependent diseases.

Basic Information

Product Name	Ki8751
CAS No.	228559-41-9
Molecular Formula	C₂₀H₁₉N₅O₂
Molecular Weight	361.40 g/mol
Synonyms	Ki8751; N-[4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-(4-fluorophenyl)urea; VEGFR2 Inhibitor Ki8751; KDR Kinase Inhibitor Ki8751; 1-(4-Fluorophenyl)-3-[4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]urea; VEGF Receptor 2 Inhibitor Ki8751
EINECS	Contact for details

Quality Control

Ki8751 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade material specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.