Description

Benzene, 1,3-Difluoro-5-(Methoxymethyl)- (9Ci) is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms and methoxymethyl groups can dramatically alter biological activity and physicochemical properties. Industrial researchers and process chemists in fine chemical and material science R&D need this high-purity intermediate to enable the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance metabolic stability, lipophilicity, and overall efficacy of the active compound.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), contributing to improved electronic properties and stability.
• Polymer & Resin Modifier: Employed to introduce fluorine and functional groups into polymer backbones, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics for high-performance coatings and engineering plastics.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems common in many advanced materials and pharmaceuticals.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on exploring new synthetic methodologies and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	Benzene, 1,3-Difluoro-5-(Methoxymethyl)- (9Ci)
CAS No.	228122-40-5
Molecular Formula	C9H10F2O
Molecular Weight	172.17 g/mol
Synonyms	1,3-Difluoro-5-(methoxymethyl)benzene; 3,5-Difluorobenzyl methyl ether; 5-(Methoxymethyl)-1,3-difluorobenzene; (3,5-Difluorophenyl)methanol methyl ether; Benzene, 1,3-difluoro-5-(methoxymethyl)-; 3,5-Difluorobenzyl Methyl Ether; 1-(Methoxymethyl)-3,5-difluorobenzene
EINECS	Contact for details

Quality Control

Our Benzene, 1,3-Difluoro-5-(Methoxymethyl)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to verify identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and our quality management system supports compliance with cGMP and ISO standards for traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.