Description

Marilixibat Chloride is a potent and selective apical sodium-dependent bile acid transporter (ASBT) inhibitor. This compound is of significant interest in pharmaceutical research and development, particularly for targeting cholestatic liver disorders. It is primarily utilized by pharmaceutical companies and research institutions engaged in developing novel therapeutics for conditions like progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription medications for cholestatic pruritus.
• Clinical Research: Investigational drug substance for clinical trials targeting bile acid-mediated liver diseases.
• Preclinical Development: Used in animal studies to evaluate pharmacokinetics, efficacy, and safety profiles of ASBT inhibition.
• Biochemical Research: Tool compound for studying bile acid transport mechanisms and intestinal reabsorption pathways in vitro.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical labs.

Basic Information

Product Name	Marilixibat Chloride
CAS No.	228113-66-4
Molecular Formula	C29H41ClN2O4S
Molecular Weight	549.17 g/mol
Synonyms	Marilixibat; LUM-001; SHP-625; 1-[[5-[4-[(4R)-4-[(3R,5R)-3,5-Dimethylpiperidin-1-yl]pyrimidin-2-yl]phenyl]-1,3,4-thiadiazol-2-yl]methyl]pyridin-1-ium chloride; (R)-1-(4-(4-(4-((R)-3,5-dimethylpiperidin-1-yl)pyrimidin-2-yl)phenyl)-1,3,4-thiadiazol-2-yl)-N-methylmethanaminium chloride
EINECS	Contact for details

Quality Control

Our Marilixibat Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and APIs. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.