Description

Tetrahydrocurcumin 4-o-β-D-Glucuronide is a major, stable, and water-soluble metabolite of the natural polyphenol curcumin, offering enhanced bioavailability and systemic exposure. This compound is valued for its potent antioxidant and anti-inflammatory properties, which are often superior to its parent molecule. It is primarily sought by manufacturers in the nutraceutical, cosmeceutical, and pharmaceutical industries for developing advanced health and wellness products.

Application

• Nutraceutical Formulations: As a key bioactive ingredient in dietary supplements targeting oxidative stress, inflammation, and metabolic health.
• Cosmeceutical & Skincare Products: Incorporated into serums, creams, and lotions for its skin-brightening, anti-aging, and protective effects against UV-induced damage.
• Pharmaceutical Research: Used as a reference standard or active pharmaceutical ingredient (API) intermediate in preclinical and clinical studies for various therapeutic applications.
• Functional Foods & Beverages: Added to enhance the antioxidant profile of health-focused food and drink products.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate metabolic pathways, bioavailability, and mechanism of action of curcuminoids.

Basic Information

Product Name	Tetrahydrocurcumin 4-o-β-D-Glucuronide
CAS No.	227466-74-2
Molecular Formula	C27H30O13
Molecular Weight	562.52 g/mol
Synonyms	THC-glucuronide; Tetrahydrocurcumin Glucuronide; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyheptane-1,7-dione 4-O-β-D-Glucuronide; Curcumin metabolite M1; THC-4-G; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyhepta-1,6-diene-3,5-dione 4-O-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Tetrahydrocurcumin 4-o-β-D-Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for research and commercial use. Certificates of Analysis (COA) documenting purity, impurities, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Microbial Limits	Complies with USP/EP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.