Description

Syk Inhibitor II is a potent and selective small molecule inhibitor targeting the spleen tyrosine kinase (Syk), a key intracellular signaling protein. This compound is a critical research tool for investigating the role of Syk in immune cell activation, inflammatory pathways, and oncogenic signaling. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biologists in drug discovery and preclinical development for autoimmune disorders, hematological cancers, and inflammatory diseases.

Application

• Biochemical Research: Used as a selective pharmacological probe to study Syk-mediated signal transduction pathways in B-cells, mast cells, and macrophages.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the development of novel Syk-targeted therapeutics for conditions like rheumatoid arthritis and lymphoma.
• Cellular Assays: Employed in in vitro studies to inhibit Syk activity and assess downstream effects on cell proliferation, differentiation, and cytokine release.
• Target Validation: Aids in validating Syk as a therapeutic target in various disease models, including allergic responses and autoimmune pathologies.
• Mechanistic Studies: Facilitates the elucidation of the molecular mechanisms involving Syk in Fc receptor and B-cell receptor signaling cascades.

Basic Information

Product Name	Syk Inhibitor II
CAS No.	227449-73-2
Molecular Formula	C₂₁H₂₀N₆O₂
Molecular Weight	388.43 g/mol
Synonyms	BAY 61-3606; BAY 61-3606 hydrochloride; BAY61-3606; 2-[(7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino]nicotinonitrile; Syk Kinase Inhibitor BAY 61-3606; 6-(5-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-7-ylamino)nicotinonitrile
EINECS	Contact for details

Quality Control

Our Syk Inhibitor II is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.