Description

Methyl Salicylate β-D-o-Glucuronide Methyl Ester is a specific glucuronide conjugate of methyl salicylate, a key metabolite in the study of salicylate pharmacokinetics and metabolism. This high-purity reference standard is critical for analytical method development, validation, and quality control in pharmaceutical and life science research. It is primarily utilized by research institutions, pharmaceutical manufacturers, and contract testing laboratories engaged in bioanalytical studies, drug metabolism and pharmacokinetics (DMPK) research, and the production of certified reference materials.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative analysis of methyl salicylate and its metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for studying the glucuronidation pathway, metabolic stability, and clearance mechanisms of salicylate-based compounds.
• Bioanalytical Method Development: Used to calibrate instruments and validate analytical methods for accuracy, precision, and specificity in compliance with GLP/GMP guidelines.
• Toxicological Research: Employed as a biomarker in studies investigating salicylate exposure, toxicity profiles, and elimination kinetics.
• Clinical Research: Supports studies monitoring therapeutic drug levels or metabolic phenotypes in patient populations.
• Manufacturing of Certified Reference Materials (CRMs): Acts as a high-purity starting material for producers of accredited reference standards for global laboratories.

Basic Information

Item	Detail
Product Name	Methyl Salicylate β-D-o-Glucuronide Methyl Ester
CAS No.	226932-59-8
Molecular Formula	C15H18O9
Molecular Weight	342.30 g/mol
Synonyms	Methyl 2-[(Methoxycarbonyl)phenoxy]-β-D-glucopyranosiduronic Acid Methyl Ester; Methyl Salicylate Glucuronide Methyl Ester; Salicylic Acid Methyl Ester Glucuronide; Methyl O-(Methyl Salicyloyl)-β-D-glucopyranosiduronate; Wintergreen Glucuronide Methyl Ester; 2-(Methoxycarbonyl)phenyl β-D-Glucopyranosiduronic Acid Methyl Ester; Betula Gaultheria Glucuronide Reference Standard
EINECS	Contact for details

Quality Control

Every batch of Methyl Salicylate β-D-o-Glucuronide Methyl Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and stability conform to the highest standards for reference materials. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.