Description

Solimastat is a potent and selective matrix metalloproteinase (MMP) inhibitor, a class of compounds with significant therapeutic potential. Its primary value lies in its targeted mechanism of action, which is critical for research into conditions involving extracellular matrix remodeling. This compound is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing treatments for cancer, cardiovascular diseases, and inflammatory disorders.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for MMP-related pathologies.
• Oncology Research: Investigated for its potential to inhibit tumor invasion, angiogenesis, and metastasis by targeting specific MMP enzymes.
• Cardiovascular Disease Studies: Used in research models for atherosclerosis, aneurysm, and heart failure where MMP activity is dysregulated.
• Inflammatory & Autoimmune Disease Models: Applied in studies of arthritis, multiple sclerosis, and other conditions involving tissue degradation.
• Biochemical Assay Development: Utilized as a precise inhibitor to characterize enzyme kinetics and selectivity profiles of MMP isoforms.
• Academic & Institutional Research: A vital tool for universities and research institutes exploring fundamental biology of proteases and tissue remodeling.

Basic Information

Product Name	Solimastat
CAS No.	226072-63-5
Molecular Formula	C20H21FN4O4
Molecular Weight	400.41 g/mol
Synonyms	BAY 12-9566; BAY-12-9566; BAY 129566; (S)-4-[[4-(4-Chlorophenoxy)benzenesulfonyl]methyl]tetrahydro-2H-pyran-4-carboxylic Acid; MMP Inhibitor BAY 12-9566; Solimastat (BAY 12-9566); Matrix Metalloproteinase Inhibitor BAY 12-9566
EINECS	Contact for details

Quality Control

Our Solimastat is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our rigorous in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.