Description

Cathepsin Inhibitor 1 CAS NO 225120-65-0 is a potent and selective cell-permeable inhibitor of cathepsin L and related cysteine proteases. This compound is a critical research tool for studying protease function in cellular processes such as protein degradation, antigen presentation, and bone resorption. It is essential for researchers in pharmaceutical development, biochemistry, and cell biology investigating cancer metastasis, osteoporosis, and autoimmune diseases.

Application

• Biomedical Research: A key reagent for investigating the role of cathepsin L in intracellular protein turnover, viral entry, and tumor cell invasion.
• Drug Discovery & Target Validation: Used in high-throughput screening (HTS) and lead optimization studies for developing novel therapeutics targeting cysteine cathepsins.
• Cancer Research: Employed to study the inhibition of tumor metastasis and angiogenesis by blocking cathepsin-mediated extracellular matrix degradation.
• Immunology Studies: Useful for probing antigen processing and presentation pathways in immune cells.
• Bone Metabolism Research: Applied in models of osteoporosis to understand cathepsin K/L involvement in bone resorption by osteoclasts.
• Virology: Investigated for its potential to inhibit viral replication processes that rely on host cell proteases.

Basic Information

Product Name	Cathepsin Inhibitor 1
CAS No.	225120-65-0
Molecular Formula	C₁₄H₁₈N₂O₃
Molecular Weight	262.31 g/mol
Synonyms	Z-Phe-Tyr(t-Bu)-diazomethyl ketone; Z-FY(t-Bu)-diazomethyl ketone; Cathepsin L Inhibitor I; Z-FY-CHN2; Benzyloxycarbonyl-Phe-Tyr(t-butyl)-diazomethyl ketone; (2S)-2-[[(2S)-2-[[(2S)-2-Benzyloxycarbonylamino-3-phenyl-propanoyl]amino]-3-[4-(tert-butoxy)phenyl]propanoyl]amino]acetic acid diazomethyl ketone
EINECS	Contact for details

Quality Control

Our Cathepsin Inhibitor 1 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for critical research applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.