Description

Mlck Inhibitor Peptide 18 CAS NO 224579-74-2 is a potent and selective cell-permeable inhibitor of myosin light chain kinase (MLCK), a key enzyme regulating smooth muscle contraction and endothelial cell permeability. This compound is a critical research tool for investigating the molecular mechanisms of vascular tone, inflammation, and barrier function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular, pulmonary, and inflammatory disease research.

Application

• Biomedical Research: Fundamental studies on smooth muscle physiology, cytoskeletal dynamics, and the role of MLCK in cellular contractility.
• Drug Discovery & Pharmacology: Used as a reference standard and pharmacological tool in high-throughput screening (HTS) campaigns and target validation for conditions like hypertension, asthma, and inflammatory bowel disease.
• Vascular Biology: Investigation of endothelial barrier function, vascular permeability, and the development of potential therapeutics for edema and sepsis.
• Cell Signaling Pathways: Elucidation of calcium/calmodulin-dependent signaling cascades and their impact on non-muscle cell motility and morphology.
• Academic & Institutional Labs: A key reagent for graduate and post-doctoral research in molecular biology, physiology, and pharmacology departments.

Basic Information

Item	Details
Product Name	Mlck Inhibitor Peptide 18
CAS No.	224579-74-2
Molecular Formula	C34H60N10O8
Molecular Weight	736.90 g/mol
Synonyms	ML-9; ML9; MLCK Inhibitor Peptide 18; 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine; 1-(5-Chloro-1-naphthalenesulfonyl)homopiperazine; CAS 224579-74-2; Myosin Light Chain Kinase Inhibitor Peptide 18
EINECS	Contact for details

Quality Control

Our Mlck Inhibitor Peptide 18 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and NMR for structural validation. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.