Description

1,4-Dichloro-7-isoquinolinesulfonyl chloride is a high-value, multi-functional chemical intermediate primarily used in advanced organic synthesis. Its core value lies in its reactive sulfonyl chloride and halogenated isoquinoline structure, enabling the construction of complex molecules for research and development. This compound is essential for pharmaceutical chemists and agrochemical researchers developing new active ingredients, particularly in medicinal chemistry for creating potential kinase inhibitors and other biologically active scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in developing advanced pesticides and herbicides by serving as a precursor for sulfonamide-based active ingredients.
• Chemical Biology Probe Synthesis: Employed to create activity-based probes (ABPs) for studying enzyme function and mechanism, leveraging its reactive sulfonyl chloride group.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with unique electronic or optical properties.
• Dye and Pigment Intermediate: Serves as a precursor for synthesizing complex heterocyclic dyes and functional colorants.

Basic Information

Product Name	1,4-Dichloro-7-isoquinolinesulfonyl Chloride
CAS No.	223671-80-5
Molecular Formula	C9H4Cl3NO2S
Molecular Weight	296.56 g/mol
Synonyms	7-Isoquinolinesulfonyl chloride, 1,4-dichloro-; 1,4-Dichloro-7-isoquinolinesulfonyl chloride; 1,4-Dichloro-7-sulfonylchloride isoquinoline; 1,4-Dichloroisoquinoline-7-sulfonyl chloride; 223671-80-5; 1,4-Dichloro-7-isoquinolinesulphonyl chloride; 1,4-Dichloro-7-isoquinolinesulfonic acid chloride
EINECS	Contact for details

Quality Control

Our 1,4-Dichloro-7-isoquinolinesulfonyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.