Description

Collagen Proline Hydroxylase Inhibitor-1 is a potent and selective small molecule inhibitor of prolyl hydroxylase enzymes, which are key regulators of collagen synthesis and stability. This compound is critical for research into fibrotic diseases, wound healing, and tissue remodeling processes. It serves as an essential biochemical tool for pharmaceutical R&D, academic research in cell biology, and the development of novel anti-fibrotic therapeutics.

Application

• Biomedical Research: Used as a key reagent to study collagen biosynthesis, hypoxia-inducible factor (HIF) pathways, and cellular responses to oxygen tension.
• Drug Discovery: Serves as a reference standard and pharmacological tool in high-throughput screening and lead optimization for anti-fibrotic drug candidates.
• Cell Culture Studies: Applied in in vitro models to investigate extracellular matrix (ECM) deposition, fibroblast activation, and the pathophysiology of fibrosis.
• Mechanistic Studies: Utilized to elucidate the role of prolyl hydroxylase domain (PHD) enzymes in various disease states, including chronic kidney disease and liver fibrosis.
• Biochemical Assay Development: Employed as a control inhibitor in enzymatic activity assays for prolyl hydroxylase targets.

Basic Information

Product Name	Collagen Proline Hydroxylase Inhibitor-1
CAS No.	223663-32-9
Molecular Formula	C₁₇H₁₄N₄O₃
Molecular Weight	322.32 g/mol
Synonyms	CPHI-1; FG-2216; Prolyl Hydroxylase Inhibitor; 3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid (4-hydroxy-phenyl)-amide; 1-(4-Hydroxybenzoyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid; PHD Inhibitor; HIF Prolyl Hydroxylase Inhibitor; Collagen Synthesis Inhibitor
EINECS	Contact for details

Quality Control

Our Collagen Proline Hydroxylase Inhibitor-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.