Description

3'-(Trifluoromethyl)[1,1'-Biphenyl]-2-Carbaldehyde is a high-purity, multi-functional aromatic aldehyde building block. This compound is valued for its trifluoromethyl-substituted biphenyl core, which imparts unique electronic and steric properties critical for advanced synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors for creating novel active ingredients. The compound serves as a key intermediate in the development of molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and advanced polymers requiring specific electronic characteristics.
• Cross-Coupling Reactions: The aldehyde and halogenated aromatic rings make it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Used to create labeled compounds and molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	3'-(Trifluoromethyl)[1,1'-Biphenyl]-2-Carbaldehyde
CAS No.	223575-93-7
Molecular Formula	C14H9F3O
Molecular Weight	250.22 g/mol
Synonyms	2-Formyl-3'-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-2-carboxaldehyde, 3'-(trifluoromethyl)-; 3'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbaldehyde; 3'-(Trifluoromethyl)biphenyl-2-carbaldehyde; 2-(3-(Trifluoromethyl)phenyl)benzaldehyde; 3'-Trifluoromethylbiphenyl-2-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 3'-(Trifluoromethyl)[1,1'-Biphenyl]-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and scale-up. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.