Description

Btp2 CAS NO 223499-30-7 is a high-purity, small molecule chemical compound widely recognized as a potent and selective inhibitor of the Orai1 calcium channel, a key component of the store-operated calcium entry (SOCE) pathway. This targeted action makes it a critical research tool for investigating calcium signaling mechanisms in various physiological and pathological contexts. It is primarily utilized by researchers and developers in the fields of immunology, neurology, and oncology for both basic scientific discovery and potential therapeutic target validation.

Application

• Biomedical Research: A fundamental tool for studying the role of store-operated calcium entry (SOCE) in cellular processes such as T-cell activation, mast cell degranulation, and neuronal signaling.
• Immunology Studies: Used to investigate calcium-dependent immune cell functions, including cytokine production and lymphocyte proliferation, offering insights into autoimmune and inflammatory diseases.
• Neurological Research: Applied in models to understand calcium dysregulation in neurodegenerative conditions like Alzheimer's disease and ischemic stroke.
• Cancer Research: Employed to explore the role of Orai1 channels in cancer cell proliferation, migration, and metastasis, identifying potential novel therapeutic targets.
• Pharmacological Profiling: Serves as a reference compound for screening and developing new SOCE inhibitors for potential drug discovery programs.
• Cell Biology Assays: Used in in vitro experiments to modulate intracellular calcium levels and study downstream effects on gene expression and cell fate.

Basic Information

Product Name	Btp2
CAS No.	223499-30-7
Molecular Formula	C32H23N3O4S
Molecular Weight	545.61 g/mol
Synonyms	BTP2; YM-58483; 3,5-Bis(trifluoromethyl)pyrazole derivative; 4-Methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide; 1-[4-[4-(5-Methyl-2-thienyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]ethanone (common misassignment, verify structure); SOCE Inhibitor BTP2; Orai1 Channel Blocker BTP2; Calcium Release-Activated Calcium (CRAC) Channel Inhibitor
EINECS	Contact for details

Quality Control

Our Btp2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. A detailed Certificate of Analysis (COA) specifying the exact purity, impurity profile, and analytical data is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.