Description

Cdk2 Inhibitor II is a potent, selective small-molecule inhibitor targeting cyclin-dependent kinase 2 (CDK2), a key regulator of the G1/S phase transition in the cell cycle. It serves as a critical research tool for probing CDK2-mediated signaling pathways, enabling mechanistic studies in oncology, cell proliferation, and drug discovery. This compound is widely utilized by pharmaceutical R&D laboratories, academic cancer biology programs, and contract research organizations conducting kinase-targeted assay development and preclinical target validation. The Cdk2 Inhibitor Ii CAS NO 222035-13-4 is supplied as a high-purity reference standard for reproducible experimental outcomes.

Application

• Preclinical investigation of CDK2-dependent tumor growth inhibition in xenograft and syngeneic mouse models
• In vitro kinase activity assays to determine IC50 values against recombinant human CDK2/cyclin E complexes
• Cell-based studies assessing G1/S arrest, RB phosphorylation status, and apoptosis induction in cancer cell lines (e.g., A549, HCT-116, MCF-7)
• Chemical probe in phosphoproteomic profiling to map downstream CDK2 substrate networks
• Lead optimization support in medicinal chemistry programs developing next-generation CDK inhibitors
• Reference standard for analytical method validation (HPLC, LC-MS) in quality control laboratories
• Co-crystallization studies for structural biology and rational inhibitor design
• Tool compound in high-content screening platforms evaluating cell cycle perturbation phenotypes

Basic Information

Product Name	Cdk2 Inhibitor II
CAS No.	222035-13-4
Molecular Formula	C22H18N6O
Molecular Weight	390.42 g/mol
Synonyms	CVT-313; (R)-2-(1-(9H-Purin-6-ylamino)ethyl)-4-(pyridin-4-yl)thiazole; (R)-2-(1-(Purin-6-ylamino)ethyl)-4-(4-pyridyl)thiazole; CVT 313; CVT313; N-(1-((4-(Pyridin-4-yl)thiazol-2-yl)ethyl)amino)-9H-purin-6-amine; Purine derivative CDK2 inhibitor; CDK2 inhibitor CVT-313; (R)-N-(1-(4-(pyridin-4-yl)thiazol-2-yl)ethyl)-9H-purin-6-amine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time), purity (≥98.5% by HPLC), and absence of critical impurities (heavy metals ≤10 ppm, residual solvents per ICH Q3C guidelines). Testing adheres to ACS Reagent Grade and EP/USP general chapters where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under dry, inert conditions. Due to its hygroscopic nature, minimize exposure to ambient humidity. Handle in a controlled environment with low moisture content (e.g., nitrogen-purged glovebox or desiccated chamber).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤1.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.