Description

Methyl6-(Trifluoromethyl)Nicotinate CAS NO 221313-10-6 is a high-value fluorinated pyridine derivative, specifically a nicotinate ester, serving as a critical building block in advanced organic synthesis. Its core value lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, enhancing their lipophilicity and stability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with improved efficacy and patent life.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS, antiviral, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, organic semiconductors, and other functional materials.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Methyl6-(Trifluoromethyl)Nicotinate
CAS No.	221313-10-6
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	Methyl 6-(Trifluoromethyl)pyridine-3-carboxylate; 6-(Trifluoromethyl)nicotinic acid methyl ester; 3-Pyridinecarboxylic acid, 6-(trifluoromethyl)-, methyl ester; Methyl 6-(trifluoromethyl)nicotinate; Methyl 6-trifluoromethylnicotinate
EINECS	Contact for details

Quality Control

Our Methyl6-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every shipment, detailing purity, identity, and impurity profiles as verified by HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.