Description

1-Bromo-2,4-Difluoro-3-Methylbenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents on a methylbenzene core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring difluoromethyl or fluorinated aromatic motifs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where halogenated aromatic rings enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated compounds for electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Stille, or Negishi couplings to form biaryl structures.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into target molecules to modulate properties like metabolic stability and lipophilicity.
• Polymer & Material Science: Used as a monomer or modifier in the synthesis of specialty polymers and advanced materials with specific thermal or chemical resistance properties.

Basic Information

Product Name	1-Bromo-2,4-Difluoro-3-Methylbenzene
CAS No.	221220-97-9
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	2,4-Difluoro-3-methylbromobenzene; 3-Methyl-2,4-difluorobromobenzene; 1-Bromo-2,4-difluoro-3-methyl-benzene; 2-Bromo-1,3-difluoro-4-methylbenzene; Benzene, 1-bromo-2,4-difluoro-3-methyl-; 3-Methyl-1-bromo-2,4-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,4-Difluoro-3-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.