Description

4-Bromo-2-Fluoro-1-Methylthiobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for coupling reactions and structural diversification.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity of the bromo-fluoro-thioanisole structure.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the introduction of complex aryl and heteroaryl groups.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on exploring new chemical spaces and reaction methodologies in organofluorine and organosulfur chemistry.

Basic Information

Product Name	4-Bromo-2-Fluoro-1-Methylthiobenzene
CAS No.	221030-79-1
Molecular Formula	C7H6BrFS
Molecular Weight	221.09 g/mol
Synonyms	1-Bromo-4-fluoro-2-(methylthio)benzene; 2-Fluoro-4-bromothioanisole; 4-Bromo-2-fluorothioanisole; 4-Bromo-2-fluoro-1-(methylthio)benzene; 2-Fluoro-4-bromo-1-methylthiobenzene; (4-Bromo-2-fluorophenyl)(methyl)sulfane; Benzene, 1-bromo-4-fluoro-2-(methylthio)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-1-Methylthiobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98.0-99.5%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.