Description

Diflomotecan is a potent topoisomerase I inhibitor belonging to the camptothecin class of compounds. This high-purity active pharmaceutical ingredient (API) is critical for advanced oncology research and the development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on next-generation cancer treatments.

Application

• Oncological Research: As a key intermediate or reference standard in the discovery and development of new topoisomerase I-targeting anticancer drugs.
• Preclinical Studies: For in vitro and in vivo pharmacological evaluation of antitumor activity and mechanism of action studies.
• Pharmaceutical Synthesis: Serves as a crucial building block in the synthetic pathways for more complex camptothecin analogs.
• Biochemical Assays: Used as a specific inhibitor to study DNA replication, transcription, and topoisomerase function in cellular models.
• Reference Standard: For quality control and analytical method development (HPLC, LC-MS) in API manufacturing.
• Drug Delivery System Development: For formulating and testing novel carrier systems like liposomes or nanoparticles to improve therapeutic efficacy.

Basic Information

Product Name	Diflomotecan
CAS No.	220997-97-7
Molecular Formula	C₂₃H₂₁F₂N₃O₅
Molecular Weight	457.43 g/mol
Synonyms	BN80915; BN 80915; 7-[(4-Methyl-1-piperazinyl)methyl]-10,11-(methylenedioxy)-20(S)-camptothecin difluorinated analog; (S)-10,11-Methylenedioxy-20-camptothecin 7-[(4-methyl-1-piperazinyl)methyl] difluorinated derivative
EINECS	Contact for details

Quality Control

Our Diflomotecan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept in a dry environment and desiccated if necessary.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.