Description

Antalarmin Hydrochloride is a potent and selective non-peptide antagonist of the corticotropin-releasing factor (CRF) receptor subtype 1 (CRF1). This compound is a critical research tool for investigating the role of the CRF system in stress-related disorders, anxiety, and depression. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in preclinical studies and neuropharmacology development.

Application

• Neuroscience Research: A key pharmacological tool for studying the central nervous system's stress response pathways and the function of CRF receptors.
• Psychopharmacology Studies: Used in preclinical models to investigate potential therapeutic interventions for anxiety, depression, and post-traumatic stress disorder (PTSD).
• Drug Discovery & Development: Serves as a reference compound or lead structure in the development of novel CRF1 receptor antagonists for psychiatric and neurological conditions.
• Academic & Institutional Research: Employed in university and research institute laboratories for fundamental studies on neuroendocrinology and behavioral pharmacology.
• Biochemical Assay Development: Used as a standard in receptor binding assays and functional tests to characterize new chemical entities targeting the CRF1 receptor.

Basic Information

Product Name	Antalarmin Hydrochloride
CAS No.	220953-69-5
Molecular Formula	C34H41ClN4O2 • HCl
Molecular Weight	609.64 g/mol
Synonyms	Antalarmin HCl; N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride; Pyrrolopyrimidine CRF1 antagonist; CRF1 Receptor Antagonist; Stresscopin antagonist
EINECS	Contact for details

Quality Control

Our Antalarmin Hydrochloride is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals to guarantee reliable and reproducible results for your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.