Description

Gw5074 CAS NO 220904-83-6 is a potent and selective small molecule inhibitor of Raf-1 kinase, a key component of the MAPK/ERK signaling pathway. This compound is a critical research tool for studying cellular proliferation, differentiation, and survival mechanisms, with significant implications for oncology and disease research. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in signal transduction and cancer biology studies.

Application

• Biomedical Research: A key reagent for investigating the Raf/MEK/ERK signaling cascade in cell culture and biochemical assays.
• Oncology Studies: Used to inhibit Raf-1 activity to study its role in tumor cell growth, survival, and metastasis.
• Signal Transduction Pathway Analysis: Essential for dissecting the functional roles of specific kinases within complex cellular networks.
• Drug Discovery & Development: Serves as a pharmacological tool for target validation and as a lead compound or reference standard in kinase inhibitor development programs.
• Academic & Preclinical Research: Facilitates fundamental research into diseases where dysregulated MAPK signaling is implicated.

Basic Information

Product Name	Gw5074
CAS No.	220904-83-6
Molecular Formula	C₁₉H₁₅N₃O₃
Molecular Weight	333.34 g/mol
Synonyms	GW 5074; GW-5074; GW5074; 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one; Raf-1 Kinase Inhibitor I; (3Z)-3-[(3,5-Dibromo-4-hydroxyphenyl)methylene]-5-iodo-1,3-dihydro-2H-indol-2-one; BDBM50108581; CCG-213022; HY-15439
EINECS	Contact for details

Quality Control

Our Gw5074 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.