Description

Aminopurvalanol A is a potent and selective cell-permeable inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK1, CDK2, and CDK5. This high-purity biochemical tool is critical for research into cell cycle regulation, apoptosis, and neurodegenerative disease pathways. It is an essential reagent for pharmaceutical R&D, academic research, and biotechnology applications focused on oncology and CNS disorders. The compound is supplied under strict quality control to ensure reliable and reproducible experimental results.

Application

• Pharmaceutical Research & Development: Used as a key reference standard and active pharmacological ingredient (API) in the discovery and development of novel CDK-targeted therapeutics for cancer and neurological conditions.
• Biochemical & Cell Biology Studies: Serves as a selective inhibitor to elucidate the specific roles of CDK1, CDK2, and CDK5 in cell cycle progression, signal transduction, and neuronal function.
• Oncology Research: Employed in in vitro and in vivo models to study tumor cell proliferation, evaluate combination therapies, and identify biomarkers of drug response.
• Neurodegenerative Disease Research: Applied in studies investigating CDK5's role in tau phosphorylation, neuronal death, and pathologies associated with Alzheimer's disease and other tauopathies.
• High-Throughput Screening (HTS): Utilized as a control compound in assay development and screening campaigns to identify new CDK inhibitors or modulators.
• Academic & Institutional Labs: A fundamental tool for basic research into mitosis, meiosis, and the molecular mechanisms controlling cell division and differentiation.

Basic Information

Product Name	Aminopurvalanol A
CAS No.	220792-57-4
Molecular Formula	C₁₉H₂₀N₆O₂
Molecular Weight	364.41 g/mol
Synonyms	9-Cyclopentyl-6-[(2-morpholin-4-ylethyl)amino]-9H-purin-2-amine; 9-Cyclopentyl-6-[(2-morpholinoethyl)amino]-9H-purin-2-amine; Aminopurvalanol; CDK Inhibitor, Aminopurvalanol A; Purvalanol A Amine Derivative; CAS 220792-57-4
EINECS	Contact for details

Quality Control

Every batch of Aminopurvalanol A is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is supplied with each shipment, guaranteeing compliance with research-grade specifications. Our quality commitment supports reproducible science and reliable sourcing for critical R&D projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.