Description

Purvalanol A is a potent and highly selective inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK2 and CDK5. This specificity makes it a critical research tool for studying cell cycle regulation, neuronal function, and apoptosis in various disease models. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neuroscience, and drug discovery programs. Purvalanol A CAS NO 220792-00-7 is essential for advancing fundamental biological research and the development of novel therapeutic agents.

Application

• Biochemical Research: A key reagent for in vitro kinase assays to study the inhibition profiles and mechanisms of cyclin-dependent kinases.
• Cell Biology Studies: Used to arrest cell cycle progression, particularly at the G1/S and G2/M phases, to investigate proliferation and checkpoint controls.
• Oncology Research: Employed as a reference compound in cancer research to explore CDK inhibition as a strategy for halting uncontrolled cell division.
• Neuroscience Research: Applied in studies of neurodegenerative diseases and neuronal development due to its potent inhibition of CDK5.
• Drug Discovery & Development: Serves as a pharmacological tool and a lead compound for the design and screening of new CDK inhibitor candidates.
• Signal Transduction Pathways: Utilized to dissect and validate specific kinase pathways involved in cellular signaling and disease etiology.

Basic Information

Product Name	Purvalanol A
CAS No.	220792-00-7
Molecular Formula	C₁₉H₁₉N₅O₂
Molecular Weight	349.39 g/mol
Synonyms	Purvalanol A; 2-(1R)-1-(6-Amino-9H-purin-9-yl)ethyl-5-hydroxy-4-methyl-3-(2-methylbenzoyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-5-one; NG 95; CDK Inhibitor Purvalanol A; 1-(6-Amino-9H-purin-9-yl)-2-[(5-hydroxy-4-methyl-3-(2-methylbenzoyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)]ethanone
EINECS	Contact for details

Quality Control

Our Purvalanol A is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.