Description

Cdk1 Inhibitor CAS NO 220749-41-7 is a potent and selective small molecule inhibitor of Cyclin-dependent kinase 1 (Cdk1), a key regulator of the cell cycle. This compound is a critical research tool for investigating cell cycle progression, mitotic entry, and the mechanisms of oncogenesis in various biological models. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for target validation and preclinical studies.

Application

• Biochemical Research: Used as a selective inhibitor in enzymatic assays to study Cdk1 kinase activity and its role in cell cycle regulation.
• Cell Biology Studies: Applied in cell culture models to induce G2/M phase arrest, facilitating the study of mitosis, checkpoint controls, and apoptosis.
• Cancer Research: A vital tool for probing the molecular pathways of tumorigenesis and evaluating the therapeutic potential of cell cycle inhibition.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in high-throughput screening and structure-activity relationship (SAR) studies for novel anti-cancer agents.
• Signal Transduction Analysis: Helps elucidate complex signaling networks where Cdk1 acts as a central node, interacting with various cyclins and other regulatory proteins.

Basic Information

Product Name	Cdk1 Inhibitor
CAS No.	220749-41-7
Molecular Formula	C₂₁H₂₀N₈O₂S
Molecular Weight	448.50 g/mol
Synonyms	RO-3306; CDK1 Inhibitor III; 6-[[2-[(3S)-3-Methyl-4-(4-morpholinyl)-1-piperazinyl]-4-pyrimidinyl]amino]-1,3-benzothiazole-2-carbonitrile; (S)-6-((2-(3-Methyl-4-morpholinopiperazin-1-yl)pyrimidin-4-yl)amino)benzo[d]thiazole-2-carbonitrile; Cyclin-dependent kinase 1 Inhibitor RO-3306
EINECS	Contact for details

Quality Control

Our Cdk1 Inhibitor is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.