Description

3-Hydroxytrimeprazine is a significant pharmaceutical intermediate and metabolite of the phenothiazine class, known for its role in the development and analysis of neuropsychiatric therapeutics. Its primary value lies in enabling advanced research into drug metabolism and serving as a critical building block for high-purity active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers specializing in psychotropic and neurological medications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced phenothiazine-derived active pharmaceutical ingredients (APIs).
• Metabolite Reference Standard: Used in analytical laboratories for the identification and quantification of drug metabolites in pharmacokinetic and bioequivalence studies.
• Pharmacological Research: Employed in academic and industrial research to study the structure-activity relationships and metabolic pathways of tricyclic compounds.
• Quality Control & Impurity Profiling: Serves as a certified reference material (CRM) for HPLC, LC-MS, and GC-MS methods to ensure API purity and regulatory compliance.
• Process Development: Utilized in scaling up and optimizing synthetic routes for related therapeutic agents within the phenothiazine family.

Basic Information

Product Name	3-Hydroxytrimeprazine
CAS No.	220698-75-9
Molecular Formula	C18H22N2OS
Molecular Weight	314.44 g/mol
Synonyms	10-[3-(Dimethylamino)-2-methylpropyl]-2-(trifluoromethyl)-10H-phenothiazin-3-ol; 3-Hydroxytrimeprazine; Trimeprazine 3-Hydroxy Metabolite; 2-(Trifluoromethyl)-10H-phenothiazin-3-ol, 10-[3-(dimethylamino)-2-methylpropyl]-; 10-[3-(Dimethylamino)-2-methylpropyl]-2-(trifluoromethyl)phenothiazin-3-ol
EINECS	Contact for details

Quality Control

Our 3-Hydroxytrimeprazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.