Description

Z-Val-Ala-Dl-Asp-Fluoromethylketone is a potent and selective fluoromethyl ketone-based caspase inhibitor, widely recognized in biochemical research. This compound is critical for studying programmed cell death (apoptosis) pathways and for the development of therapeutic agents targeting related diseases. It is an essential tool for researchers and pharmaceutical developers in the fields of oncology, neurology, and immunology, where precise modulation of caspase activity is required.

Application

• Apoptosis Research: A key biochemical tool for inhibiting specific caspases to elucidate cell death mechanisms in various disease models.
• Pharmaceutical Development: Used as a reference standard and lead compound in the discovery of novel anti-apoptotic and anti-inflammatory drugs.
• Neuroscience Studies: Applied in research on neurodegenerative conditions such as Alzheimer's and Parkinson's disease to understand caspase-mediated neuronal loss.
• Oncology Research: Utilized to investigate the role of caspases in cancer cell survival and resistance to chemotherapy.
• Inflammatory Disease Models: Employed to study caspase-1 (interleukin-1β converting enzyme) involvement in autoimmune and inflammatory disorders.
• Biochemical Assay Development: Serves as a critical control and calibration standard in high-throughput screening (HTS) assays for caspase activity.

Basic Information

Product Name	Z-Val-Ala-Dl-Asp-Fluoromethylketone
CAS No.	220644-02-0
Molecular Formula	C20H30FN3O7
Molecular Weight	443.47 g/mol
Synonyms	Z-VAD-FMK; Z-Val-Ala-Asp(OMe)-FMK; Caspase Inhibitor Z-VAD-FMK; Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethyl ketone; Z-VAD(OMe)-FMK; Caspase-3 Inhibitor Z-DEVD-FMK related; (Benzyloxycarbonyl)valyl-alanyl-aspartyl fluoromethyl ketone; Ac-DEVD-CHO analog
EINECS	Contact for details

Quality Control

Every batch of Z-Val-Ala-Dl-Asp-Fluoromethylketone is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for advanced research and development. A detailed Certificate of Analysis (COA), providing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile, is supplied with each shipment to guarantee reproducible and reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.